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      Saurabh Sharma

      Saurabh Sharma

      Assistant Professor

      Assistant Professor

      Saurabh Sharma is an Assistant Professor in the School of Biotechnology at Shoolini University. He specialises in bioinformatics, computational biology, and biological data science. He earned his PhD in Molecular Biology and Computational Biology from the Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, with his doctoral research focusing on cardiac-specific exosomes in Angiotensin-II induced cardiac fibrosis.

       Asst Prof Sharma brings over four years of diverse academic and industry experience, having served as a Scientist at BioCore Analytics, Science Writer at JoVE (Journal of Visual Experiments), and DNA Analyst at the Central Forensic Science Laboratory. He is CSIR-NET qualified and has authored 25+ research publications, including significant contributions to COVID-19 drug discovery pipelines during his postdoctoral tenure at PGIMER.

       His technical expertise spans Python/R programming, machine learning frameworks, molecular dynamics simulations, and NGS pipeline development. Asst Prof Sharma's unique combination of computational skills and biological insights positions him at the forefront of modern biotechnology research and education.

       

      Publication

      1. Khan S, Sharma S, Tandon C, Nayak D, Manchanda R, Kumari K, et al. Attenuation of hTERT-dependent pathways by Hydrastis canadensis as a novel mechanism for inhibiting breast cancer cell proliferation. Chemical Biology Letters. 2025 July 2;12(3):1272–1272.
      2. Sharma S, Kumaravel J, Kaur G, Medhi B, Prakash A. Target Identification and Validation. In Academic Press; 2023.
      3. Sarma P, Kaur H, Hafezi F, Bhattacharyya J, Kirubakaran R, Prajapat M, et al. Short- and long-term safety and efficacy of corneal collagen cross-linking in progressive keratoconus: A systematic review and meta-analysis of randomized controlled trials. Taiwan J Ophthalmol. 2023;13(2):191–202.
      4. Kumar S, Singh H, Prajapat M, Sarma P, Bhattacharyya A, Kaur H, et al. Structural-Based Virtual Screening of FDA-Approved Drugs Repository for NSP16 Inhibitors, Essential for SARS-COV-2 Invasion Into Host Cells: Elucidation From MM/PBSA Calculation. Bioinform Biol Insights. 2023 Jan 1;17:11779322231171777.
      5. Kaur G, Prajapat M, Singh H, Sarma P, Bhadada S kumar, Shekhar N, et al. Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions. Sci Rep. 2023 June 8;13(1):9337.
      6. Chauhan A, Avti PK, Shekhar N, Prajapat M, Sarma P, Sangwan N, et al. An insight into the simulation directed understanding of the mechanism in SARS CoV-2 N-CTD, dimer integrity, and RNA-binding: Identifying potential antiviral inhibitors. Journal of Biomolecular Structure and Dynamics. 2022 Dec 26;40(24):13912–24.
      7. Sharma S, Prakash A, Sarma P, Medhi B. Machine Learning Techniques for Development of Drugs Against Coronavirus Disease 2019 (COVID-19): A Case Study Protocol. In: Roy K, editor. In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols. Available from: https://doi.org/10.1007/7653_2020_70
      8. Sharma AR, Batra G, Saini L, Sharma S, Mishra A, Singla R, et al. Valproic acid and Propionic acid modulated mechanical pathways associated with Autism Spectrum Disorder at prenatal and neonatal exposure. CNS & Neurological Disorders Drug Targets. 2021;
      9. Sarma P, Bhattacharyya A, Prakash A, Kaur H, Prajapat M, Borah M, et al. Yogic Neti-Kriya Using Povidone Iodine: Can it have a Preventive Role Against SARS-CoV-2 Infection Gateway? Indian J Otolaryngol Head Neck Surg. 2021 Oct 17;1–7.
      10. Prajapat M, Handa V, Sarma P, Prakash A, Kaur H, Sharma S, et al. Update on geographical variation and distribution of SARS-nCoV-2: A systematic review. Indian J Pharmacol. 2021 Aug;53(4):310–6.
      11. Kaur H, Shekhar N, Sharma S, Sarma P, Prakash A, Medhi B. Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes. Pharmacol Rep. 2021 Jan 3;
      12. Kaur H, Sarma P, Bhattacharyya A, Sharma S, Chhimpa N, Prajapat M, et al. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review. European Journal of Pharmacology. 2021 Sept 5;906:174233.
      13. Kaur H, Kaur M, Bhattacharyya A, Prajapat M, Thota P, Sarma P, et al. Indian contribution toward biomedical research and development in COVID-19: A systematic review. Indian J Pharmacol. 2021 Feb;53(1):63–72.
      14. Avti P, Chauhan A, Shekhar N, Prajapat M, Sarma P, Kaur H, ... Sharma S, et al. Computational basis of SARS-CoV 2 main protease inhibition: an insight from molecular dynamics simulation based findings. Journal of Biomolecular Structure and Dynamics. 2021 May 13;0(0):1–11.
      15. Allu PKR, Kiranmayi M, Mukherjee SD, Chirasani VR, Garg R, Vishnuprabu D, Sharma S, et al. Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders. Diabetes. 2021 Dec 3;71(3):538–53.
      16. Shekhar N, Sarma P, Prajapat M, Avti P, Kaur H, Raja A, ..., Sharma S, et al. In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations. Msystems. 2020;5(5).
      17. Sarma P, Bhattacharyya A, Kaur H, Prajapat M, Prakash A, Kumar S, ..., Sharma S, et al. Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis. Indian J Pharmacol. 2020 Dec;52(6):535–50.
      18. Prajapat M, Shekhar N, Sarma P, Avti P, Singh S, Kaur H, ..., Sharma S et al. Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2. Journal of Molecular Graphics and Modelling. 2020;101:107716.
      19. Bhattacharyya A, Kumar S, Sarma P, Kaur H, Prajapat M, Shekhar N, et al. Safety and efficacy of lopinavir/ritonavir combination in COVID-19: A systematic review, meta-analysis, and meta-regression analysis. Indian Journal of Pharmacology. 2020 July 1;52(4):313.
      20. Subramanian L, Maghajothi S, Singh M, Kesh K, Kalyani A, Sharma S, et al. A Common Tag Nucleotide Variant in MMP7 Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor. Hypertension. 2019;74(6):1448–59.
      21. Subramanian L, Khan AA, Allu PKR, Kiranmayi M, Sahu BS, Sharma S, et al. A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders. J Biol Chem. 2017 Aug 25;292(34):13970–85.
      22. Singh GB, Raut SK, Khanna S, Kumar A, Sharma S, Prasad R, et al. MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy. Mol Cell Biochem. 2017 Jan 1;424(1–2):1–11.
      23. Singh GB, Khanna S, Raut SK, Sharma S, Sharma R, Khullar M. DUSP-1 gene expression is not regulated by promoter methylation in diabetes-associated cardiac hypertrophy. Ther Adv Cardiovasc Dis. 2017 June;11(5–6):147–54.
      24. Kiranmayi M, Chirasani VR, Allu PKR, Subramanian L, Martelli EE, Sahu BS, ..., Sharma S, et al. Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway. Hypertension. 2016 Jan 1; HYPERTENSIONAHA.116.06568.
      25. Khullar M, Sharma S. Pharmacogenetics of Essential Hypertension [Internet]. Genetics and Pathophysiology of Essential Hypertension. IntechOpen; 2012. Available from: https://www.intechopen.com/chapters/31016
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