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      Lokender Kumar

      Lokender Kumar

      Associate Professor

      Associate Professor

      Lokender Kumar is an Associate Professor and Academic Incharge at the School of Biotechnology. Before joining Shoolini, he was a Research Assistant Professor (Postdoc) at the Cell Biology, Biochemistry, and Biophysics Laboratory, as well as the Single Molecule Biophysics Laboratory in the Department of Physics at the Colorado School of Mines, Golden, Colorado, USA, from 2016 to 2022. 

      Asst Prof Kumar earned his PhD in Microbiology from Panjab University and a Master of Science in Microbiology, with a Gold Medal from Himachal Pradesh University, Shimla. Recognised for his strong academics, he is a recipient of the DST-Inspire Fellowship from the Department of Science and Technology, Government of India, and has secured a CSIR-UGC junior research fellowship. 

      Specialising in Human-Microbe interactions, Asst Prof Kumar's research focuses on cellular signalling processes and the impact of microorganisms on host cells. His expertise spans diverse areas, including bacterial communication (quorum sensing), antibiotic-resistant biofilms in human food, and the medicinal potential of plants from the Western Himalayas. He also explores innovative strategies using bacteriophages to combat bacterial infections and investigates the crucial role of gut microbes in human health. 

      In the academic realm, Asst Prof Kumar teaches the Foundation of Data Science in biotechnology and microbiology. Leveraging his multidisciplinary training, he integrates advanced data science tools into his teaching methods, providing students with cutting-edge insights. 

      Asst Prof Kumar is dedicated to improving research in microbiology and biotechnology. He leads a project supported by Divyasampark iHUB Devices, Materials and Technology Foundation at IIT Roorkee, and the Department of Science and Technology (DST) of the Indian government. This project is dedicated to developing a cost-effective automatic device for detecting and quantifying antimicrobial activity, showcasing his dedication to practical applications of research. 

      Publication

      1. Kharga, K., Dhar, I., Kashyap, S., Sengupta, S., Kumar, D. and Kumar, L., (2023). Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm. World Journal of Microbiology and Biotechnology, 39(10), 268. 
      2. Kumar, N., Asija, S., Deswal, Y., Kumar, D., Jindal, D.K., Kumar, L., Kumar, S. and Devi, J., (2023). Insighting the inhibitory potential of new diorganotin (IV) complexes derived from tridentate ligands: Synthesis, structural elucidation and biological evaluation. Inorganic Chemistry Communications, 110953. 
      3. Kumar, L., Bisen, M., Harjai, K., Chhibber, Shavkatjon Azizov, S., Lalhlenmawia, H., Kumar, D., (2023) Advances in Nanotechnology for Biofilm Inhibition. ACS Omega, 8, 24, 21391–21409 
      4. Sharma, S., Shukla, M.K., Sharma, K.C., Tirath, Kumar, L., Anal, J.M.H., Upadhyay, S.K., Bhattacharyya, S. and Kumar, D., (2023). Revisiting the therapeutic potential of gingerols against different pharmacological activities. Naunyn-Schmiedeberg's Archives of Pharmacology, 396(4), pp.633-647. 
      5. Li, S., Roger, L.M., Kumar, L., Lewinski, N.A., Klein-Seetharaman, J., Putnam, H.M. and Yang, J., (2023). High-frequency imagery to capture coral tissue (Montipora capricornis) response to environmental stress, a pilot study. PloS one, 18(3), p.e0283042. 
      6. Kharga, K., Kumar, L. and Patel, S.K.S., (2023). Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis. Biomedicines, 11(3), p.765. 
      7. Sharma, N., Srivastava, N., Devi, B., Kumar, L., Kumar, R. and Kumar Yadav, A., (2023). Synthesis, Biological Evaluation and in Silico Study of N‐(2‐and 3‐Pyridinyl) benzamide Derivatives as Quorum Sensing Inhibitors against Pseudomonas aeruginosa. Chemistry & Biodiversity, 20(3), p.e202201191. 
      8. Kumar, L., Kumar, S., Sandeep, K. and Patel, S.K.S., (2023). Therapeutic Approaches in Pancreatic Cancer: Recent Updates. Biomedicines, 11(6), p.1611. 
      9. Chanana, I., Kaur, P., Kumar, L., Kumar, P. and Kulshreshtha, S., (2023). Advancements in microalgal biorefinery technologies and their economic analysis and positioning in energy resource market. Fermentation, 9(3), p.202. 
      10. Chanana, I., Sharma, A., Kumar, P., Kumar, L., Kulshreshtha, S., Kumar, S. and Patel, S.K.S., (2023). Combustion and Stubble Burning: A Major Concern for the Environment and Human Health. Fire, 6(2), p.79. 
      11. Kumar, L., Brenner, N., Sledzieski, S., Olaosebikan, M., Roger, L.M., Lynn-Goin, M., Klein-Seetharaman, R., Berger, B., Putnam, H., Yang, J. and Lewinski, N.A., (2023). Transfer of knowledge from model organisms to evolutionarily distant non-model organisms: The coral Pocillopora damicornis membrane signaling receptome. PloS one, 18(2), p.e0270965. 
      12. Sharma, N., Srivastava, N., Kaushal, A., Das, B., Vashistha, A., Kumar, L., Kumar, R. and Kumar Yadav, A., (2023). Synthesis, in Silico Study and Biological Evaluation of N‐(Benzothiazol/Thiazol‐2‐yl) benzamide Derivatives as Quorum Sensing Inhibitors against Pseudomonas aeruginosa. Chemistry & Biodiversity, 20(9), p.e202300647. 
      13. Kumar, L., Patel, S.K.S., Kharga, K., Kumar, R., Kumar, P., Pandohee, J., Kulshresha, S., Harjai, K. and Chhibber, S., (2022). Molecular mechanisms and applications of N-acyl homoserine lactone-mediated quorum sensing in bacteria. Molecules, 27(21), p.7584. 
      14. Kumar, L., Vizgaudis, W., & Klein‐Seetharaman, J. (2022). Structure‐based survey of ligand binding in the human insulin receptor. British Journal of Pharmacology, 179(14), 3512-3528. 
      15. Kumar, L., Bisen, M., Khan, A., Kumar, P. and Patel, S.K.S., (2022). Role of Matrix Metalloproteinases in Musculoskeletal Diseases. Biomedicines, 10(10), p.2477. 
      16. Kamboj, S., Harms, C., Wright, D., Nash, A., Kumar, L., Klein-Seetharaman, J., & Sarkar, S. K. (2022). Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights. Scientific reports, 12(1), 5764. 
      17. Kumar, L., Brenner, N., Brice, J., Klein-Seetharaman, J. and Sarkar, S.K., (2021). Cephalosporins interfere with quorum sensing and improve the ability of Caenorhabditis elegans to survive Pseudomonas aeruginosa infection. Frontiers in Microbiology, 12, p.598498. 
      18. Kumar, L., Nash, A., Harms, C., Planas-Iglesias, J., Wright, D., Klein-Seetharaman, J., & Sarkar, S. K. (2020). Allosteric communications between domains modulate the activity of matrix metalloprotease-1. Biophysical journal, 119(2), 360-374. 
      19. Kumar, L., Planas-Iglesias, J., Harms, C., Kamboj, S., Wright, D., Klein-Seetharaman, J., & Sarkar, S. K. (2020). Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin. Scientific reports, 10(1), 20615. Kumar, L., Brice, J., Toberer, L., Klein-Seetharaman, J., Knauss, D. and Sarkar, S.K., (2019). Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides. PLoS One, 14(3), p.e0214411. 
      20. Kumar, L., Cox, C.R. and Sarkar, S.K., (2019). Matrix metalloprotease-1 inhibits and disrupts Enterococcus faecalis biofilms. PloS one, 14(1), p.e0210218. 
      21. Kumar, L., Colomb, W., Czerski, J., Cox, C.R. and Sarkar, S.K., (2018). Efficient protease based purification of recombinant matrix metalloprotease-1 in E. coli. Protein expression and purification, 148, pp.59-67. 
      22. Bala, A., Kumar, L., Chhibber, S. and Harjai, K., (2015). Augmentation of virulence related traits of pqs mutants by Pseudomonas quinolone signal through membrane vesicles. Journal of Basic Microbiology, 55(5), pp.566-578. 
      23. Kumar, L., Chhibber, S., Kumar, R., Kumar, M. and Harjai, K., (2015). Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa. Fitoterapia, 102, pp.84-95. 
      24. Kumar, L., Chhibber, S. and Harjai, K., (2014). Structural alterations in Pseudomonas aeruginosa by zingerone contribute to enhanced susceptibility to antibiotics, serum and phagocytes. Life sciences, 117(1), pp.24-32. 
      25. Kumar, L., Chhibber, S. and Harjai, K., (2014). Zingerone suppresses liver inflammation induced by antibiotic mediated endotoxemia through down regulating hepatic mRNA expression of inflammatory markers in Pseudomonas aeruginosa peritonitis mouse model. PLoS One, 9(9), p.e106536. 
      26. Kumar, L., Chhibber, S. and Harjai, K., (2013). Zingerone inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1. Fitoterapia, 90, pp.73-78. 
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