Anuradha Sourirajan

About

Prof Anuradha Sourirajan teaches biotechnology programmes to undergrads and postgraduate students. Dr Sourirajan received her PhD degree in Biochemistry from Indian Institute of Science, Bangalore, and pursued postdoctoral research at Center for Cancer Research, National Cancer Institute, NIH, USA in the field of cell cycle kinases and yeast meiosis. She is a recipient of the fellow award for research excellence from the National Institutes of Health, USA. Her research interests include understanding cell cycle regulation of yeast meiosis, exploration of cell cycle kinases as anti-cancer target, exploiting medicinal plants of Western Himalayas for cancer therapeutics and fungal infections, salt-stress control using halophiles, and affordable solutions for nutrition. Her team has already identified phytochemicals with potential cell cycle inhibitory activity for cancer therapeutics and unique essential oils to treat candidiasis, which are being developed into therapeutic formulations. 

She has 60 publications in internationally and nationally reputed journals in the field of biological research with highest impact factor of 14.2 and filed 42 patents in the areas of drug discovery and enzyme biotechnology. Her potential as an independent scientist has been endorsed by the extramural research funding from DBT (BioCare scheme), and DST-SERB, Govt. of India.

 

Publications

• Bhattacharya R, Dev K and Sourirajan A (2021) Antiviral activity of bioactive phytocompounds against coronavirus: An update.  Journal of Virological Methods 290, 114070.
• Gautam M, Rolta R, Kumar V, Sourirajan A, Sharma DR, Dev K (2020) Comparative antimicrobial and synergistic potential of extracts of leaves of Zanthoxylum armatum DC. from different geographical regions of Himachal Pradesh, India. Plant Archives 20 (2) 8127-8135
• Rolta R, Salaria D, Kumar V, Patel CN, Sourirajan A, Baumler DJ, Dev K (2020). Molecular docking studies of phytocompounds of Rheum emodi Wall with proteins responsible for antibiotic resistance in bacterial and fungal pathogens: in silico approach to enhance the bio-availability of antibiotics. Journal of Biomolecular Structure and Dynamics https://doi.org/10.1080/07391102.2020.1850364.
• Gupta S, Sharma P, Dev K, Sourirajan A (2020) Isolation of gene conferring salt tolerance from halophilic bacteria of Lunsu, Himachal Pradesh, India. Journal of Genetic Engineering and Biotechnology 18:57 (doi.org/10.1186/s43141-020-00070-6).
• Rolta R, Sharma A, Sourirajan A, Dev K (2020) Combination between antibacterial and antifungal antibiotics with phytocompounds of Artemisia annua:  A strategy to control drug resistance pathogens. Journal of Ethnopharmacology 266 (2021) 113420 (doi.org/10.1016/j.jep.2020.113420).
• Nidhi P, Rolta R, Kumar V, Dev K, Sourirajan A (2020) Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans. Journal of Ethnopharmacology 262 (2020) 113135 (DOI: 10.1016/j.jep.2020.113135)
• Rolta R, Yadav R, Salaria D, Trivedi S, Imran M, Sourirajan A, Baumler DJ, Dev K (2020) In silico screening of hundred phytocompounds of ten medicinal plants as potential inhibitors of nucleocapsid phosphoprotein of COVID-19: An approach to prevent virus assembly. Journal of Biomolecular Structure and Dynamics https://doi.org/10.1080/07391102.2020.1804457.
• Sharma S, Gupta S, Sourirajan A, Dev K (2020) Halophilic plant growth promoting bacteria as potential bioinoculants for sustainable agriculture under salt stress. Journal of Xi'an University of Architecture & Technology XII (IV): 3532-3562. 
• Rolta R, Kumar V, Sourirajan A, Upadhyay NK, Dev K (2020) Phytocompounds of three medicinal plants (Juniperus communis, Urtica dioica and Coleus forskohlii) of North West Himalayas increases the potency of antibacterial and antifungal antibiotics. Plant Archives 20 (Supplement 2): 481-489.
• Guleria S, Kumar V, Chandel SR, Sharma N, Sourirajan A, Khosla PK, Dev K (2020) Antioxidant and antimicrobial activity of ethanolic extract and its fractions from fruit and leaves of Terminalia chebula from Himachal Pradesh, India. Plant Archives 20 (2 October 2020, Ref. No:PA3/6140).
• Sharma S, Sourirajan A, Dev K (2020) S. cerevisiae ER Membrane Protein complex subunit 4 (EMC4) plays a crucial role in eIF2B mediated translation regulation and survival under stress conditions. Journal of Genetic Engineering and Biotechnology 18, Article number: 15 (DOI: 10.1186/s43141-020-00029-7). 
• Kumar R, Sharma N, Rolta R, Lal UR, Sourirajan A, Dev K, Kumar V (2020) Thalictrum foliolosum DC: An unexplored medicinal herb from North western Himalayas with potential against fungal pathogens and scavenger of reactive oxygen species. Biocatalysis and Agricultural Biotechnology, Volume 26, July 2020, 101621.
• Sharma S, Chaudhary R, Rolta R, Sharma N, Sourirajan A, Dev K, Kumar V (2020) Effect of solvent on yield, phytochemicals and in vitro antioxidant potential of Rhododendron arboretum. Research Journal of Pharmacy and Technology 13 (12): December-2020.
• Sharma N, Kumar V, Chopra MP, Sourirajan A, Dev K, El-Shazly M (2020) Thalictrum foliolosum: A lesser unexplored medicinal herb from the Himalayan region as a source of valuable benzyl isoquinoline alkaloids. Journal of Ethnopharmacology 255: 112736 (doi: 10.1016/j.jep.2020.112736).
• Rolta R, Kumar V, Sourirajan A, Upadhyay NK, Dev K (2020) Bioassay guided fractionation of rhizome extract of Rheum emodi wall as bio-availability enhancer of antibiotics against bacterial and fungal pathogens. Journal of Ethnopharmacology 257:112867 (doi.org/10.1016/j.jep.2020.112867).
• Bisht, G., Srivastava, S., Kulshreshtha, R., Sourirajan, S., Baumler, DJ., Dev, K (2020) Applications of Red Pigments of psychrophilic Rhodonelum psychrophylum GL8 in health, food and antimicrobial finishes on textiles. Process Biochemistry 94: 15-29 (doi.org/10.1016/j.procbio.2020.03.021).
• Sharma, P., Gupta, S., Sourirajan, A., Baumler, DJ., Dev, K (2020) Molecular evolution of Thermophilic Geobacillus species isolated from Tattapani Hotspring (India) and the Worldwide Distribution. Current Trends in Biotechnology and Pharmacy 14(1):16-32 (DOI: 10.5530/ctbp.2020.1.2).
• Chauhan, S., Samanta, S., Sharma, N., Thakur, J.K., Dev, K., Sourirajan, A (2019) Saccharomyces cerevisiae Polo-like kinase, Cdc5 exhibits ATP-dependent Mg2+-enhanced kinase activity in vitro. Heliyon 5 (12), e03050 (https://doi.org/10.1016/j.heliyon.2019.e03050).
• Sharma D, Sharma P, Dev K, Sourirajan A (2019) Endoglucanase gene of M42 aminopeptidase/ endoglucanase family from thermophilic Bacillus sp. PW1 and PW2 isolated from Tattapani Hot Spring, Himachal Pradesh, India. Journal of Genetic
• Engineering and Biotechnology 17: 4. https://doi.org/10.1186/s43141-019-0001-8. (Scopus Cite score: 2.06)
• Sheoran S, Nidhi P, Kumar V, Singh G, Lal UR, Sourirajan A, Dev K. (2019) Altitudinal variation in gallic acid content in fruits of Phyllanthus emblica L. and its correlation with antioxidant and antimicrobial activity. Vegetos 32: 387. https://doi.org/10.1007/s42535-019-00048-x.  (Impact factor-0.56, Scopus Cite Score-0.18)
• Gupta S, Sharma P, Dev K, Baumler DJ, and Sourirajan A. (2019) Draft Genome Sequence of Halobacillus trueperi SS1, isolated from Lunsu, a saltwater body in the Northwest Himalayas. Microbiology Resource Announcements 8 (10), e01710-18. doi: 10.1128/MRA.01710-18. Scopus Cite score 1.01
• Sharma P, Gupta S, Sourirajan A, Baumler DJ, and Dev, K. (2019) Draft Genome sequence of hyperthermophilic, halotolerant Parageobacillus toebii PW12, isolated from the Tattapani hot spring, Northwest Himalayas. Microbiology Resource Announcements 8 (4): e01163-18. Cite score 1.01
• Rangra, S, Kumar, V, Guleria, S, Sharma, N, Sourirajan A, Khosla, P.K., Baumler D J, and Dev K. (2019) Sequential fractionation by organic solvents enhances the antioxidant and antibacterial activity of ethanolic extracts of fruits and leaves of Terminalia bellerica from north Western Himalayas, India. Pharmacognosy Journal 11(1): 94-101. (Scopus Cite Score- 0.83)
• Sharma D, Dev K, Sourirajan A. (2019) A Report on Metal Enhanced, Solvent Tolerant
• Endoglucanase from Strict Thermophilic Bacillus sp. PW1 and Bacillus sp. PW2 of North
• West Himalayas. Biological Forum – An International Journal 11 (1): 222-230. (Journal Impact factor: 2.9 indexed in Clarivate Analytics)
• Bisht, G, Sourirajan A, Baumler DJ, and Dev, K. (2018) 16S rRNA gene amplicon data set-based bacterial diversity in a water-soil sample from Pangong Tso Lake, a high-altitude grassland lake of the Northwest Himalayas. Microbiology Resource Announcements 7 (17): e01192-18.
• Sharma, S, Sourirajan A, Baumler, DJ, and Dev K. (2018) Identification of thermophilic Flavobacterium and Anoxybacillus in unexplored Tatapani hotspring of Kishtwar District of Jammu and Kashmir: A North Western Himalayan State. Current Trends in Biotechnology and Pharmacy 12 (3) 245-256.
• Nidhi, P., Kumari, R., Thakur, S., Devi, R., Sharma, R., Kashyap, S., Dev, K., and Sourirajan, A. (2018).  Role of Essential Oils of Medicinal Plants (Eucalyptus globulus, Thuja occidentalis, Rosmarinus officinalis, Lavandula officinalis) to Treat Broad Spectrum Bacterial and Fungal Pathogens and as Antioxidants in Food and Health (December 11, 2018). International Conference on New Horizons in Green Chemistry & Technology (ICGCT) 2018. Available at SSRN: https://ssrn.com/abstract=3299291 or http://dx.doi.org/10.2139/ssrn.3299291.
• Rolta, R., Sharma, A., Kumar, V., Chauhan, P., Sourirajan, A., and Dev, K. (2018). Traditional Medicinal Plants of Higher Altitude of Himachal Pradesh as Functional Food Ingredient Cum Food Preservative and Bioavailability Enhancer of Anifungal Antibiotics (December 11, 2018). International Conference on New Horizons in Green Chemistry & Technology (ICGCT) 2018. Available at SSRN: https://ssrn.com/abstract=3299285 or http://dx.doi.org/10.2139/ssrn.3299285.\
• Sharma A, Kumar V, Shukla RK, Dev K, Sourirajan A (2018) Resurrection of the Fern "Cheilanthes albomarginata Clarke" Involves Utilization of Trehalose as Energy Source and Accumulation of Protective Stress Metabolites. International Journal of Biochemistry and Physiology 3(3): 000131.
• Rolta R, Sharma A, Kumar V, Sourirajan A, Baumler DJ, and Dev K (2018) Methanolic extracts of the rhizome of R. emodi act as bioenhancer of antibiotics against bacteria and fungi and antioxidant potential. Medicinal Plant Research, 8(9): 74-85.
• Vaidya S, Dev K, and Sourirajan A (2018) Distinct osmoadaptation strategies in the strict halophilic and halotolerant bacteria isolated from Lunsu salt water body of North West Himalayas. Current Microbiology Feb 26. doi: 10.1007/s00284-018-1462-8.
• Kumar V, Sharma N, Sourirajan A, Khosla PK, and Dev K (2018) Comparative evaluation of antimicrobial and antioxidant potential of ethanolic extract and its fractions of bark and leaves of Terminalia arjuna from north-western Himalayas, India. Journal of Traditional and Complementary Medicine 8(1):100-106.
• Sharma S, Sourirajan A, Dev, K (2017) Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in Eukaryotic Initiation Factor 2B (eIF2B) mediated Translation Control and Stress Response. 3 Biotech 7 (3): 223.
• Sharma N, Vaid R, Dev K, and Sourirajan A. (2017) Polo-like Kinase (PLK) S. Choi (ed), Encyclopedia of Signaling Molecules.1-7. DOI 10.1007/978-1-4614-6438-9_101760-1.
• Hangloo S, Sourirajan A, and Dev K (2016) Metal independent and detergent stable lipases from Aeromonas and Pseudomonas spp. and their role in bioremediation. International   Journal of Biology, Pharmacy and Allied Sciences 5(11): 2781-2799.
• Thakur, R., Sourirajan, A., Dev, K (2016) Isolation and characterization of caffeine degrading Pseudomonas putida species and Bacillus licheniformis from
• thermal hot springs and tea garden of Himachal Pradesh, north west Himalayas. IJBPAS, 5(8): 1869-1888.
• Hangloo S, Sourirajan A, Raina C, Chaubey A, and Dev K (2016) Isolation and characterization of extracellular lipase producing bacterial isolates from effluent waste of paint industry. Current Trends in Biotechnology and Pharmacy 10 (3): 261-273.
• Kumar V, Sourirajan A, Dev K, and Khosla PK (2016) Comparative Antioxidant Potential of Bark and Leaves of Terminalia arjuna (Roxb) Wight & Arn from Himachal Pradesh. Int. J. Pharmaceutical and Phytopharmacology Res. 6(1):27-33. 
• Vaid R, Dev K, Lichten M, and Sourirajan A (2016) Generation of an inducible system to express Polo like kinase, Cdc5 as TAP fusion protein during meiosis in Saccharomyces cerevisiae. 3 Biotech 6 (2): 1-6.
• Vaid R, Sharma N, Chauhan N, Deshta A, Dev K and Sourirajan A (2016) Functions of Polo-Like kinases: A journey from Yeast to Humans. Protein and Peptide Letters 23: 185-197.
• Sharma N, Dev K, and Sourirajan A (2016) A recombinant system for plo1 expression: an amenable tool to study Schizosaccharomyces pombe polo-like kinase in vitro. IJBPAS, 5(5): 1046-1057.
• Gupta S, Sharma P, Dev K and Sourirajan A (2016) Halophilic bacteria of Lunsu produce an array of industrially important enzymes with salt-tolerant activity. Biochemistry Research International vol. 2016, Article ID 9237418, 10 pages, 2016. doi:10.1155/2016/9237418.
• Sharma P, Gupta S, Sourirajan A and Dev K (2015) Characterization of extracellular thermophilic cellulase from Geobacillus sp. isolated from Tattapani Hot Spring of Himachal Pradesh, India. International Journal of Advanced Biotechnology Research 6 (3): 433-442.
• Deshta A, Dev K and Sourirajan A (2015) Cloning and expression of Polo-like kinase (CaCdc5) from Candida albicans. International Journal of Advanced Scientific and Technical Research 6 (5) 127-133.
• Sharma A, Kashyap S, Dev K and Sourirajan A (2015). A report on resurrection activity of the fern ‘Cheilanthes albomarginata clarke’ from various regions of Himachal Pradesh, India. International Journal of Life Science and Pharma Research 5 (4) L1-L7.
• Chauhan S, Samanta S, Thakur JK and Sourirajan A (2015) Cloning, expression and purification of functionally active Saccharomyces cerevisiae Polo-like Kinase, Cdc5 in E. coli. Journal of Applied Biology and Biotechnology 3(4): 20-24.
• Sharma P, Gupta S, Sourirajan A and Dev K (2015) Characterization of extracellular thermophilic amylase from Geobacillus sp. isolated from Tattapani hot spring of Himachal Pradesh, India. Current Biotechnology 4: 1-8.
• Gupta S, Sharma P, Dev K, Srivastava M and Sourirajan A (2015) A diverse group of halophilic bacteria exist in Lunsu, a natural salt water body of Himachal Pradesh, India. Springer Plus 4:274.
• Kumar A, Dev K and Sourirajan A (2015) Screening of medicinal and aromatic plants of Himachal Pradesh for antiproliferative activities against budding yeast Saccharomyces cerevisiae. International Journal of Pharma and Biosciences 6(3): (B) 280 – 288.
• Kumar T, Sourirajan A and Dev K (2015) Isolation and characterization of psychrotolerant Serratia quinivorans secreting β-galactosidase. Universal Journal of Microbiology Research 3(1): 1-9.
• Suman R, Sharma P, Gupta S, Sourirajan A and Dev K (2015) A novel psychrophilic Janthinobacterium lividum MMPP4 isolated from Manimahesh Lake of Chamba District of Himachal Pradesh, India. Journal of Biochemical Technology 6(1): 846-851.
• Sharma V, Sharma HV, Mehta D, Chhabra B, Thakur D, Sourirajan A and Dev K (2014) Comparative analysis of antibacterial and antifungal properties of traditional medicinal plants of Shimla and Solan, Himachal Pradesh. International Journal of Pharmacognosy and Phytochemical Research 6(1): 18-26.
• De Muyt A, Jessop L, Kolar E, Sourirajan A, Chen J, Dayani Y and Lichten M (2012) BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism. Molecular Cell 46: 43-53.     
• Sourirajan A and Lichten M (2008) Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis. Genes and Development 22: 2627-2632.
• Tripathi P, Anuradha S, Ghosal G and Muniyappa K (2006) Selective binding of meiosis-specific yeast Hop1 protein to the Holliday junctions distorts the DNA structure and its implications for junction migration and resolution. Journal of Molecular Biology 364: 599-611.
• Anuradha S, Tripathi P, Mahajan K and Muniyappa K 2005 Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores. Biochemical and Biophysical Research Communications 336: 934-941.
• Anuradha S and Muniyappa K 2005 Molecular aspects of meiotic chromosome synapsis and recombination. Progress in Nucleic Acid Research and Molecular Biology 79: 49-132
• Anuradha S and Muniyappa K 2004 Saccharomyces cerevisiae Hop1 zinc-finger motif is the minimal region required for its function in vitro. Journal of Biological Chemistry 279: 28961-28969.
• Anuradha S and Muniyappa K 2004 Meiosis-specific yeast Hop1 protein promotes synapsis between double-stranded DNA helices via the formation of guanine quartets. Nucleic Acids Research 32: 2378-2385.
• Muniyappa K, Anuradha S and Byers B 2002 Yeast meiosis-specific Hop1 binds to G4 DNA and promotes its formation

List of Patents filed (Indian and PCT):