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Dr. Jagattaran Das

Professor
Faculty of Pharmaceutical Sciences

A mix of academic and corporate experience, Dr. Jagattaran Das has post-doctoral experience at the University of Tokyo, Japan and went to University of Konstanz, Germany as an Alexander von Humboldt fellow. He received CNRS, Gif-sur-Yvette, Franceas Cancer Research Fellow and has worked in professional capacities at Panacea Biotec Ltd., Dr. Reddy's Laboratories Ltd. and Ray Chemicals Pvt. Ltd.

Dr. Das has a Ph. D. (Thesis - Development of New Synthetic Methods for Organic Synthesis) from Indian Institute of Science, Bangalore. Dr. Das was also Junior Research Fellow - Indian Institute of Technology, Kanpur, Junior Research Fellow - Visva Bharati University (Santiniketan), M. Sc. Chemistry) Visva Bharati University (Santiniketan), and B. Sc.(Hons) Visva Bharati University (Santiniketan).

  1. S. Baskaran, J. Das, S. Chandrasekaran, J. Org. Chem. 1989, 54, 5182-5184. Heterogeneous permanganate oxidations: an improved procedure for the direct conversion of olefins to α-diketones/α-dihydroxy ketones
  2. J. Das, S. Chandrasekaran, Synth. Commun. 1990, 20, 907-912. A convenient methodology for the selective reduction of carboxylic acids with benzyltriethylammonium borohydride-chlorotrimethylsilane
  3. M. S. Syamala, J. Das, S. Baskaran, S. Chandrasekaran, J. Org. Chem. 1992, 57, 1928-1930. A novel and highly β-stereoselective epoxidation of Δ5-unsaturated steroids with permanaganate ion
  4. J. Das, S. Chandrasekaran, Tetrahedron, 1994, 50, 11709-11720. Heterogeneous permanganate oxidations: synthesis of medium ring keto-lactones via substituent directed oxidative cyclisation
  5. J. Das, P. K. Choudhury, S. Chandrasekaran, Tetrahedron, 1995, 51, 3389-3394. An improved procedure for the synthesis of allylic spiro-γ-lactone
  6. J. Das, R. R. Schmidt, Eur. J, Org. Chem., 1998, 1609-1613. Convenient glycoside synthesis of amino sugars: Michael-type addition to 2-nitro-D-galactal
  7. N. Yoshikawa, Y. M. A. Yamada, J. Das, H. Sasai, M. Shibasaki, J. Am. Chem. Soc., 1999, 121, 4168-4178. Direct catalytic asymmetric aldol reaction
  8. J. Prabhakaran, H. Lhermite, J. Das, T. K. Sasi-Kumar, D. S. Grierson, Synlett., 2000, 658-662. The synthesis of a sulfone containing analogue of the Esperamicin-A1 aglycone: a hetero Diels-Alder approach
  9. S. Matsunaga, J. Das, J. Roels, E. M. Vogl, N, Yamamoto, T. Iida, K. Yamaguchi, M. Shibasaki, J. Am. Chem. Soc., 2000, 122, 2252-2260. Catalytic enantioselective meso-epoxide ring opening reaction with phenolic oxygen nucleophile promoted by gallium heterobimetallic multifunctional complexes
  10. Y. S. Kim, S. Matsunaga, J, Das, A. Sekine, T. Oshima, M. Shibasaki, J. Am. Chem. Soc., 2000, 122, 6506-6507. Stable, storable and reusable asymmetric catalyst: a novel La-linked-BINOL complex for the catalytic asymmetric Michael reaction
  11. G. A. Winterfeld, J. Das, R. R. Schmidt, Eur. J. Org. Chem., 2000, 3047-3050. Convenienet synthesis of nucleosides of 2-deoxy-2-nitro-D-galactose and N-acetyl-D-galactosamine
  12. K. Pachamuthu, A. Gupta, J. Das, R. R. Schmidt, Y. D. Vanker, Eur. J. Org. Chem., 2002, 1479-1483. An easy route to 2-amino-β-C-glycosides by conjugate addition to 2-nitroglycals
  13. N. Selvakumar, D. Srinivas, M. K. Khera, M. Sitaram Kumar, N. V. S. Rao Mamidi, H. Sarnaik, C. Chandraseakhar, B. S. Rao, M. A. Raheem, J. Das, J. Iqbal, R. Rajagopalan, J. Med. Chem., 2002, 3953-3962. Synthesis of conformationally constrained analogues of Linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolodinones
  14. H. Z. S. Huma, R. Halder, S. S. Kalra, J. Das, J. Iqbal, Tet. Lett., 2002, 43, 6485-6488. Cu(I) catalysed three component coupling-protocol for the synthesis of quinoline derivatives
  15. T. V. R. S. Sastry, B. Banerji, S. K. Kumar, A. C. Kunwar, J. Das, J. P. Nandy, J. Iqbal, Tet. Lett., 2002, 43, 7621-7625.A facile conversion of a 310 helical structure to a cyclic β-turn mimic in dehydro-phenylalanine derived small peptides through ring closing metathesis.
  16. B. Gopalakrishnan, A. Khandelwal, S. A. Rajjak, N. Selvakumar, J. Das, S. Trehan, J. Iqbal, M. S. Kumar, Bioorg. Med. Chem., 2003, 2569-2574. Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of tricyclic oxazolidinones as antibacterial agents
  17. J. Das, C. V. Laxman Rao, T. V. R. S. Sastry, R. Roshiah, P. Gowri Sankar, A. Khadeer, M. Sitaram Kumar, A. Mallik, N. Selvakumar, J. Iqbal, S. Trehan, Bioorg. Med. Chem. Lett.,2005, 15, 337-343. Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones
  18. J. Das, S. N. Patil, R. Awasthi, C. P. Narasimhulu, S. Trehan, Synthesis, 2005, 11, 1801-1806. An easy access to arylazides from aryl amines under neutral conditions
  19. B. Ravikanth, P. Venkatesh, D. V. Prajakta, C. P. Narasimhulu, T. V. R. S. Sastry, J. Das, R. Mullangi, N. R. Srinivas, Eur. J. Drug Metab. Pharmaoc.,2005, 30, 187-193. Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid
  20. M. Takhi, C. Murugan, M. Munikumar, K. M. Bhaskarreddy, G. Singh, K. Sreenivas, M. Sitaram Kumar, N. Selvakumar, J. Das, S. Trehan, J. Iqbal, Bioorg. Med. Chem. Lett., 2006, 2391-2395. Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent
  21. N. Selvakumar, B. Y. Reddy, G. S. Kumar, M. K. Khera, D. Srinivas, M. Sitaram Kumar, J. Das, J. Iqbal, S. Trehan, Bioorg. Med. Chem. Lett., 2006, 4416-4419. Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid
  22. J. Das, M. Sitaram Kumar, D. Subrahmanyam, T. V. R. S. Sastry, C. Prasad Narasimhulu, C. V. Laxman Rao, M. Kannan, M. Rosaiah, Riti Awasthi, Santosh N. Patil, H. M. Sarnaik, N. V. S. Rao Mamidi, N. Selvakumar & Javed Iqbal, Bioorg. Med. Chem., 2006, 14, 8032-8042. Substituent Activity Relationship studies on new azolo benzoxazepinyl oxazolidinone
  23. N. Selvakumar, A. M. Raheem, M. K. Khera, T. V. Rajale, M. S. Kumar, S. Kandepu,  J. Das, R. Rajagopalan, J. Iqbal, S. Trehan, Bioorg. Med. Chem. Lett., 2006, 4169-4172. Influence of ethylene-oxy spacer group on the activity of linezolid: Synthesis of potent antibacterials possessing a thiocarbonyl group
  24. N. Selvakumar, G. S. Kumar, A. M. Raheem, G. G. Rajulu, S. Sharma, M. S. Kumar, J. Das, J. Iqbal, S. Trehan, Eur. J. Med. Chem., 2007, 42, 538-543. Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids

List of Patents

  1. N. Selvakumar, J. Das, J. Iqbal, M. Sitaram Kumar, R, Rajagopalan, B. B. Lohray, S. Baskaran, N. V. S. R. Mamidi, WO02/051819. Heterocyclic compounds having antibacterial activity: Process for their preparation and pharmaceutical compositions containing them
  2. J. Das, N. Selvakumar, S. Trehan, M. Sitaram Kumar, N. V. S. R. Mamidi, J. Iqbal, R. Rajagopalan, WO03/059894. Novel antibacterial compounds: Process for their preparation and pharmaceutical compositions containing them
  3. J. Das, N. Selvakumar, S. Trehan, J. Iqbal, M. Sitaram Kumar. WO2004/101531. Antiinfective 1,2,3 triazole derivatives, process for their preparation and pharmaceutical compositions containing them
  4. J. Das, N. Selvakumar, S. Trehan, J. Iqbal, M. Sitaram Kumar, WO2004/106329. Novel antiinfective compounds and their pharmaceutical compositions
  5. N. Selvakumar, J. Das, M. Takhi, S. Trehan, J. Iqbal, M. Sitaram Kumar, WO2005/035528. Triazole derivatives as antibacterial agents
  6. J. Das, M. Takhi, N. Selvakumar, S. Trehan, J. Iqbal, M. Sitaram Kumar, K. Srinivas. WO2005/082892. Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
  7. R. Jain, S. Trehan, J. Das, G. Kaur, S. Kanwar, M. Sitaram Kumar, WO2008/090570. Novel antimicrobials
  8. M. Takhi, J. Das, J. Iqbal, N. Selvakumar, K. Sreenivas, M. Sitaram Kumar, WO2008/143649. Novel oxazolidinone compounds as antiinfective agents
  9. R. Jain, S. Trehan, J. Das, N. Singh, G. K. Nanda, M. Sitaram Kumar, S. K. Sharma. WO2009/093269. Novel heterocyclic compounds
  10. R. Jain, S. Trehan, J. Das, S. Kanwar, M. Sitaram Kumar. WO2009/116090. Novel antimicrobials
  11. S. V. Kessar, S. K. Kulkarni, R. Jain, S. Trehan, M. Sitaram Kumar, J. Das, G. Kaur, K. N. Singh, S. Lata,  A. Dhir. WO2009/118765. Novel monoamine re-uptake inhibitor
  12. R. Jain, S. Trehan, J. Das, S. Kanwar, M. Sitaram Kumar, S. K. Sharma. WO2010/058423. Novel antimicrobials
  13. R. Jain, S. Trehan, J. Das, G. Kaur, S. Kanwar, N. Singh, G. K. Nanda, M. Sitaram Kumar, S. K. Sharma. WO2010/150281. Novel azabicyclohexanes
  14. R. Jain, S. Trehan, T. V. R. S. Sastry, G. K. Nanda, J. Das, M. Sitaram Kumar, S. K. Sharma. WO2011/070592. Novel sugar derivatives as SGLT2 inhibitors
  15. R. Jain, S. Trehan, J. Das, N. Singh, S. K. Sharma. WO2012/042539. 3-Azabicyclo[3.1.0]hexane compounds useful for the treatment of CNS disorders
  16. R. Jain, S. Trehan, J. Das, G. K. Nanda, T. V. R. S. Sastry, N. Singh, S. K. Sharma.  WO2012/172566. Novel SGLT Inhibitors
  17. R. Jain, S. Trehan, J. Das, G. K. Nanda, T. V. R. S. Sastry, N. Singh, S. K. Sharma.  WO2013/038429. Novel SGLT Inhibitors

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